45 Studies, primarily performed in high-income countries in which the duration of untreated psychosis is usually less than 5 years, have reported that a longer duration of untreated psychosis is associated with more severe positive and negative symptoms and lower rates of … Methodologically sound studies that have examined the association of DUP and outcome of schizophrenia in these countries are lacking. Some have suggested that minority ethnic groups have longer treatment delays, and this could lead to worse outcomes. Perkins DO, Gu H, Boteva K, et al. A: The length of time between the start of psychotic symptoms and the beginning of treatment is called the duration of untreated psychosis or DUP. AIM: Duration of untreated psychosis (DUP) is considered as a key prognostic variable in psychosis. DUP is generally determined as the time from the onset of psychotic symptoms to the initiation of treatment or first clinical presentation, when a diagnosis of first-episode psychosis may be given. Context : Longer duration of untreated psychosis (DUP) is known to be associated with poorer outcome of schizophrenia. To assess the impact of duration of untreated psychosis (DUP) on baseline and 18-month follow-up characteristics controlling for relevant confounders in an epidemiological first-episode psychosis (FEP) cohort.The Early Psychosis Prevention and Two influential meta-analyses have established that duration of untreated psychosis (DUP), the time between the onset of psychosis and initiation of appropriate treatment, is correlated with poor outcome (Marshall et al., 2005; Perkins et al., 2005). Studies have shown that the earlier treatment is initiated for psychosis, the better the long-term outcomes for the patient. Duration of untreated psychosis (DUP) is one of the few potentially modifiable outcome predictors in psychosis. Long DUP as a predictor of poor short-term outcome has been addressed in previous meta-analyses, but the long-term effects of DUP remain unclear. It has been postulated that a longer DUP leads to a poorer prognosis. Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis - Volume 205 Issue 2 - Matti Penttilä, Erika Jääskeläinen, Noora Hirvonen, Matti Isohanni, Jouko Miettunen Am J Psychiatry. Duration of untreated psychosis has a significant effect on treatment adherence in the initial recovery phase. This study examined outcome and factors related to it after one year of treatment of schizophrenia patients who were ill for many years and not previously treated. We searched electronic databases and conducted forward … This study by Addington et al provides another substantial advance in the burgeoning literature on the importance of the duration of untreated psychosis (DUP) in relation to outcomes in the early course of schizophrenia. This study examined outcome and factors related to it after one year of treatment of schizophrenia patients who were ill for many years and not previously treated. Association Between Duration of Untreated Psychosis and Outcome in Cohorts of First-Episode Patients: A Systematic Review October 2005 Archives of General Psychiatry 62(9):975-83 Duration of untreated psychosis (DUP) is the time between onset of psychotic symptoms and initiation of antipsychotic medication. OBJECTIVE The duration of untreated psychosis may influence response to treatment, reflecting a potentially malleable progressive pathological process. For over a decade, the DUP has been studied as a potential predictor of a variety of outcomes. follow-ups of ten years or more) are somewhat limited. Objective: The duration of untreated psychosis (DUP) influences treatment outcome in schizophrenia but its relevance in untreated patients, ill for a very long duration, is not known. (Original Article, Report) by "Shanghai Archives of Psychiatry"; Psychology and mental health Schizophrenia Care and treatment Patient outcomes The duration of untreated psychosis, or DUP, is measured as the time from the beginning of psychotic symptoms to the time a person starts treatment for those symptoms or a diagnosed condition. The authors reviewed the literature on the association of duration of untreated psychosis with symptom severity at first treatment contact and with treatment outcomes and conducted a meta-analysis examining these relationships. The aim of this study was to evaluate the potential association between DUP and very long-term outcome (16-33 yrs) of schizophrenia by means of a retrospective design. 2005;62:975-983 URATION OF UNTREATED psychosis (DUP) is de-fined as the time from manifestationofthefirst psychotic symptom to initiation of adequate antipsychotic drug treatment. Untreated psychosis has long been associated with worse clinical outcomes in patients with schizophrenia. There is a requirement for services to reduce the duration of untreated psychosis, as this has been shown to be associated with better long-term outcomes. Download Duration of Untreated Psychosis (DUP) Measurement by Jo Smith. Association between duration of untreated psychosis and in cohorts of first-episode outcome patients: a systematic review. In general, research has shown that treatments for psychosis work better when they are delivered closer to the time … AB - Duration of untreated psychosis (DUP) is the time from manifestation of the first psychotic symptom to initiation of adequate treatment. What is the duration of untreated psychosis (DUP)? Duration of untreated psychosis and outcomes What is duration of untreated psychosis (DUP)? Figure 1 shows the differences in access to mental 2 The Canadian Journal of Psychiatry -To reduce duration of untreated psychosis (DUP), which has been associated with worse outcomes … sociation between shorter duration of untreated psy-chosis and better outcome at follow-up. Psychosis is one of the most debilitating psychiatric conditions with limited options to improve outcomes. by Marshall and colleagues (2) of DUP and outcomes among patients with FEP. This presentation was delivered by Jo Smith at the Worcestershire Early Intervention Service Study day, 9th June 2011. Bradford DW, Perkins DO, Lieberman JA. Duration of untreated psychosis predicts functional and clinical outcome in children and adolescents with first-episode psychosis: A 2-year longitudinal study DUP is also known to be longer in lower- and middle-income countries. The implementation guideline recommends: 14 to 35 year age entry criteria; First three years of psychotic illness; Aim to reduce the duration of untreated psychosis to less than 3 months The duration of untreated psychosis (DUP) influences treatment outcome in schizophrenia but its relevance in untreated patients, ill for a very long duration, is not known. Arch Gen Psychiatry 2005;62:975–83. Previous studies have associated a longer DUP with a poor prognosis, but few of them were performed in countries with low and middle level of income. If so, outcome might be improved through earlier detection and treatment. 2 Accumulating studies have shown that a longer DUP is associated with poorer outcomes for people with first-episode psychosis (FEP), … U2 - 10.1001/archpsyc.62.9.975. 1 One key strategy is reducing the duration of untreated psychosis (DUP), the time from the first symptom of psychosis to the start of treatment. est association between DUP and outcome, which sup-ports the case for clinical trials that examine the effect of reducing DUP. An extended duration of untreated psychosis (DUP) is associated with poor outcome in first-episode psychosis (FEP). Free Online Library: Duration of untreated psychosis and clinical outcomes of first-episode schizophrenia: a 4-year follow-up study. Duration of untreated psychosis (DUP), defined as delay in treatment with antipsychotic medication, was found to be associated with an unfavorable course of schizophrenia. Duration of Untreated Psychosis (DUP) is commonly defined as the time interval between onset of definite positive psychotic symptoms and first appropriate treatment. 2. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Q Does duration of untreated psychosis affect outcome for people with first episode psychosis? Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis. We systematically reviewed the literature on racial and ethnic differences in DUP in patients with FEP. 2005;162(10):1785-1804. D Arch Gen Psychiatry. The purpose of this study was to determine whether the dynamics of long-term treatment outcomes in the 12-year follow-up (1997–2000) in patients suffering from schizophrenia are dependent on the duration of untreated psychosis (DUP). Marshall M, Lewis S, Lockwood A, et al . AIMS To analyse the associations between DUP and long-term outcomes of schizophrenia. “Larger longitudinal studies of longer duration are needed to examine the association between [duration of untreated psychosis], hippocampal volume and clinical outcomes.” – by Savannah Demko Yet, it is unclear whether a longer DUP causes worse outcomes or whether reported associations have alternative explanations. Longer DUP has been associated with poorer prognosis (see the DUP and outcomes topic). Studies performed to assess the relevance of duration of untreated psychosis (DUP) as a predictor of long-term outcome (i.e. BACKGROUND Duration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. DO - 10.1001/archpsyc.62.9.975 Pharmacological management of first-episode schizophrenia and related nonaffective psychoses. METHODS: Data from 2 cohorts of patients with first episode psychosis … 1. 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